Biophysical Characterisation of SH2 Domains: a semisynthetic strategy

Abstract

Src Homology 2 (SH2) domains are protein modules of ~100 aa and play an integral role in eukaryotic cell signaling. Cell receptors can respond to extracellular messages by the autophosphorylation of intracelluar Tyr residues. These phosphorylated Tyr (pTyr) residues are then recognised by SH2 domain-containing signaling proteins. The propagation of… (More)

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