Biophysical Basis for Three Distinct Dynamical Mechanisms of Action Potential Initiation

  title={Biophysical Basis for Three Distinct Dynamical Mechanisms of Action
                    Potential Initiation},
  author={Steven A. Prescott and Yves De Koninck and Terrence J. Sejnowski},
  journal={PLoS Computational Biology},
  pages={500 - 544}
Transduction of graded synaptic input into trains of all-or-none action potentials (spikes) is a crucial step in neural coding. Hodgkin identified three classes of neurons with qualitatively different analog-to-digital transduction properties. Despite widespread use of this classification scheme, a generalizable explanation of its biophysical basis has not been described. We recorded from spinal sensory neurons representing each class and reproduced their transduction properties in a minimal… CONTINUE READING
Highly Influential
This paper has highly influenced 18 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
92 Citations
55 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 92 extracted citations


Publications referenced by this paper.
Showing 1-10 of 55 references

Simulating, Analyzing, and Animating Dynamical Systems: A Guide to Xppaut for Researchers and Students

  • B Ermentrout
  • 2002
Highly Influential
3 Excerpts

Similar Papers

Loading similar papers…