Biophysical Basis for Three Distinct Dynamical Mechanisms of Action Potential Initiation

@article{Prescott2008BiophysicalBF,
  title={Biophysical Basis for Three Distinct Dynamical Mechanisms of Action
                    Potential Initiation},
  author={Steven A. Prescott and Yves De Koninck and Terrence J. Sejnowski},
  journal={PLoS Computational Biology},
  year={2008},
  volume={4},
  pages={500 - 544}
}
Transduction of graded synaptic input into trains of all-or-none action potentials (spikes) is a crucial step in neural coding. Hodgkin identified three classes of neurons with qualitatively different analog-to-digital transduction properties. Despite widespread use of this classification scheme, a generalizable explanation of its biophysical basis has not been described. We recorded from spinal sensory neurons representing each class and reproduced their transduction properties in a minimal… CONTINUE READING
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