Biophysical, pharmacological, and functional characteristics of cloned and native mammalian two-pore domain K+ channels

  title={Biophysical, pharmacological, and functional characteristics 
of cloned and native mammalian two-pore domain K+ channels},
  author={D. Lotshaw},
  journal={Cell Biochemistry and Biophysics},
  • D. Lotshaw
  • Published 2007
  • Biology, Medicine
  • Cell Biochemistry and Biophysics
  • The mammalian family of two-pore domain K+ (K2P) channel proteins are encoded by 15 KCNK genes and subdivided into six subfamilies on the basis of sequence similarities: TWIK, TREK, TASK, TALK, THIK, and TRESK. K2P channels are expressed in cells throughout the body and have been implicated in diverse cellular functions including maintenance of the resting potential and regulation of excitability, sensory transduction, ion transport, and cell volume regulation, as well as metabolic regulation… CONTINUE READING
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