Biopharming the SimpliRED™ HIV diagnostic reagent in barley, potato and tobacco

  title={Biopharming the SimpliRED™ HIV diagnostic reagent in barley, potato and tobacco},
  author={Petra H.D. Sch{\"u}nmann and Greg Coia and Peter M. Waterhouse},
  journal={Molecular Breeding},
This is the first report of an antibody-fusion protein expressed intransgenic plants for direct use in a medical diagnostic assay. By the use ofgene constructs with appropriate promoters, high level expression of ananti-glycophorin single-chain antibody fused to an epitope of the HIV virus wasobtained in the leaves and stems of tobacco, tubers of potato and seed ofbarley. This fusion protein replaces the SimpliRED™ diagnostic reagent,used for detecting the presence of HIV-1 antibodies in human… CONTINUE READING

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