Biopharmaceutics and Relevant Pharmacokinetics

  title={Biopharmaceutics and Relevant Pharmacokinetics},
  author={John G. Wagner},
Sustained release spherical agglomerates of polymethacrylates containing mefenamic acid: in vitro release, micromeritic properties and histological studies
Mefenamic acid (MA) spherical agglomerates (SAs) were prepared with various polymethacrylates having different permeability characteristics (Eudragit RS 100, Eudragit RL 100 and Eudragit L 100) and
Formulation Development of Oral Mucoadhesive Coated Terbutaline Sulphate Tablets Using Some Natural Materials Extracted from Edible Fruits Available in India
It was seen that both in vitro and in vivo drug release study of terbutaline sulphate showed the same release profile, and extended drug release profile for tablets prepared with natural materials than synthetic polymers was seen.
On some stochastic formulations and related statistical moments of pharmacokinetic models
The deterministic and stochastic model for a linear compartment system with constant coefficients is presented, and the MRT and VRT provide a set of new meaningful response measures for pharmacokinetic analysis and they give added insight into the system kinetics.
Pharmacokinetics of isoniazid metabolism in man
Detailed pharmacokinetic studies undertaken on a slow and a rapid acetylator of isoniazid enabled approximate first-order rate constants to be calculated for the metabolic processes involved in the
Potential source of error in absorption rate calculations
It has been demonstrated that use of a two- term Taylor expansion in simplifying the calculation of absorption rates of drugs in multicompartmental systems may lead to serious errors. These errors
The potential of nanomaterials for drug delivery, cell tracking, and regenerative medicine
1Mawson Institute, University of South Australia, Mawson Lakes, SA 5095, Australia 2School of Advanced Manufacturing, University of South Australia, Mawson Lakes, SA 5095, Australia 3Department of
Pharmacokinetic study of orally administered zinc in humans: Evidence for an enteral recirculation
Observations from a pharmacokinetic study of the serum zinc profile after oral administration of a pharmacological dose of the metal are consistent with the previously reported endogenous secretion of zinc, a physiological mechanism contributing to zinc homeostasis.
Dynamics of target-mediated drug disposition.
  • L. Peletier, J. Gabrielsson
  • Biology
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
  • 2009
Volumes of distribution and mean residence time of drugs with linear tissue distribution and binding and nonlinear protein binding
AbstractBased on a generalized model, equations for calculating the mean residence time in the body at single dose (MRT) and at steady state (MRTss), apparent steady-state volume of distribution (
Numerical deconvolution by least squares: Use of prescribed input functions
  • D. Cutler
  • Mathematics
    Journal of Pharmacokinetics and Biopharmaceutics
  • 2005
A new method for numerical deconvolution is described, for use in calculating drug input rates. The method is based on the least-squares criterion and is applicable when the input function can be