Biopharmaceutical considerations in topical ocular drug delivery.

  title={Biopharmaceutical considerations in topical ocular drug delivery.},
  author={N. Michael Davies},
  journal={Clinical and experimental pharmacology & physiology},
  volume={27 7},
1. Despite the accessibility of the front of the eye, efficient delivery of drug to treat various ocular disorders is a challenge to the formulation scientist. The majority of ophthalmic medications are formulated as eye drops. Due to anatomical constraints, the volume that can be administered is limited to approximately 30 microL. This, together with the efficient clearance system that exists in the front of the eye, makes it difficult to maintain an effective pre-ocular drug concentration for… CONTINUE READING
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