Biopharmaceutical benchmarks 2010
@article{Walsh2010BiopharmaceuticalB2, title={Biopharmaceutical benchmarks 2010}, author={Gary Walsh}, journal={Nature Biotechnology}, year={2010}, volume={28}, pages={917-924} }
Over the past four years, several new types of experimental biologic treatment have received commercial registration, but the emergence of biosimilars represents the biggest shift in the biologic approval landscape.
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References
SHOWING 1-10 OF 29 REFERENCES
Biopharmaceutical benchmarks
- Biology, MedicineNature Biotechnology
- 2000
Less than 20 years after the first biopharmaceutical, insulin, was approved, a new generation of products is superseding replacement proteins and enzyme therapies in biotechnology's pipeline.
Biopharmaceutical benchmarks 2006
- Biology, MedicineNature Biotechnology
- 2006
The rate of biopharmaceutical approvals has leveled off, but some milestones bode well for the future.
Toward biosimilar monoclonal antibodies
- BiologyNature Biotechnology
- 2008
To what extent is the existing framework for biosimilars in Europe likely to be applicable to monoclonal antibodies?
Fresh from the biologic pipeline—2009
- BiologyNature Biotechnology
- 2010
Human antibodies take center stage, as they pile up in the list of approved biologics in 2009. Cormac Sheridan reports.
Certolizumab pegol
- MedicineNature Reviews Drug Discovery
- 2008
In April 2008, certolizumab pegol (Cimzia; UCB), a tumour-necrosis factor blocker, was approved by the US FDA for the treatment of adult patients with moderate-to-severe Crohn's disease who have not…
Quadrivalent human papillo-mavirus recombinant vaccine
- BiologyNature Reviews Drug Discovery
- 2006
In June 2006, a quadrivalent human papillomavirus (types 6, 11, 16 and 18) recombinant vaccine (Gardasil; Merck) was approved by the US FDA for the prevention of several diseases, including cervical…
Expression systems for therapeutic glycoprotein production.
- BiologyCurrent opinion in biotechnology
- 2009
Post-translational modifications in the context of therapeutic proteins
- BiologyNature Biotechnology
- 2006
A better understanding of the relationship between structure and function is understood for many PTMs but remains incomplete for others, particularly in the case of complex PTMs, such as glycosylation.
A special report on India's biotech scenario: advancement in biopharmaceutical and health care sectors.
- Biology, Political ScienceBiotechnology advances
- 2010