Biopersistences of man-made vitreous fibers and crocidolite fibers in rat lungs following short-term exposures.

@article{Musselman1994BiopersistencesOM,
  title={Biopersistences of man-made vitreous fibers and crocidolite fibers in rat lungs following short-term exposures.},
  author={Reilly Patrick Musselman and W C Miiller and Walter Eastes and John G. Hadley and Ole Kamstrup and Philippe Th{\'e}venaz and Thomas W. Hesterberg},
  journal={Environmental Health Perspectives},
  year={1994},
  volume={102},
  pages={139 - 143}
}
Biopersistence of commercial man-made vitreous fibers (MMVF) and crocidolite were studied in Fischer 344 rats. MMVF used were size-selected to be rat-respirable, and rats were exposed nose-only 6 h/day for 5 days to gravimetric concentrations (30 mg/m3) of two fiber glass compositions--a rockwool, and a slagwool--or to 10 mg/m3 of long-fibered crocidolite, or to filtered air. Animals were sacrificed at 1 hr, 1, 5, 31, 90, 180, 270, 365, and 545 days after exposure stopped. Fibers were recovered… CONTINUE READING
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