Biopartitioning micellar chromatography to predict mutagenicity of aromatic amines.

  title={Biopartitioning micellar chromatography to predict mutagenicity of aromatic amines.},
  author={Sagrario Torres-Cartas and Yolanda Mart{\'i}n-Biosca and Rosa Mar{\'i}a Villanueva-Cama{\~n}as and Salvador Sagrado and Mar{\'i}a Jos{\'e} Medina-Hern{\'a}ndez},
  journal={European journal of medicinal chemistry},
  volume={42 11-12},
Mutagenicity is a toxicity endpoint associated with the chronic exposure to chemicals. Aromatic amines have considerable industrial and environmental importance due to their widespread use in industry and their mutagenic capacity. Biopartitioning micellar chromatography (BMC), a mode of micellar liquid chromatography that uses micellar mobile phases of Brij35 in adequate experimental conditions, has demonstrated to be useful in mimicking the drug partitioning process into biological systems. In… CONTINUE READING