Bioorthogonal, two-component delivery systems based on antibody and drug-loaded nanocarriers for enhanced internalization of nanotherapeutics.

@article{Hapuarachchige2014BioorthogonalTD,
  title={Bioorthogonal, two-component delivery systems based on antibody and drug-loaded nanocarriers for enhanced internalization of nanotherapeutics.},
  author={Sudath Hapuarachchige and Wenlian Zhu and Yoshinori Kato and Dmitri Artemov},
  journal={Biomaterials},
  year={2014},
  volume={35 7},
  pages={2346-54}
}
Nanocarriers play an important role in targeted cancer chemotherapy. The optimal nanocarrier delivery system should provide efficient and highly specific recognition of the target cells and rapid internalization of the therapeutic cargo to reduce systemic toxicity as well as to increase the cytotoxicity to cancer cells. To this end, we developed a two-step… CONTINUE READING