Bioorganometallic Chemistry and Malaria

@article{Biot2010BioorganometallicCA,
  title={Bioorganometallic Chemistry and Malaria},
  author={Christophe Biot and Daniel Dive},
  journal={Medicinal Organometallic Chemistry},
  year={2010},
  volume={32},
  pages={155 - 193}
}
  • C. Biot, D. Dive
  • Published 2010
  • Biology
  • Medicinal Organometallic Chemistry
This chapter summarizes recent developments in the design, synthesis, and structure–activity relationship studies of organometallic antimalarials. It begins with a general introduction to malaria and the biology of the parasite Plasmodium falciparum, with a focus on the heme detoxification system. Then, a number of metal complexes from the literature are reported for their antiplasmodial activity. The second half of the chapter deals with the serendipitous discovery of ferroquine, its mechanism… Expand
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