Biomonitoring of tobacco smoke carcinogenicity by dosimetry of DNA adducts and genotyping and phenotyping of biotransformational enzymes: a review on polycyclic aromatic hydrocarbons.

@article{Besaratinia2002BiomonitoringOT,
  title={Biomonitoring of tobacco smoke carcinogenicity by dosimetry of DNA adducts and genotyping and phenotyping of biotransformational enzymes: a review on polycyclic aromatic hydrocarbons.},
  author={Ahmad Besaratinia and Jos C. S. Kleinjans and Frederik Jan van Schooten},
  journal={Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals},
  year={2002},
  volume={7 3},
  pages={
          209-29
        }
}
In this review article, we summarize the data on tobacco smoke carcinogenicity in relation to DNA adduct dosimetry and genotyping and phenotyping of biotransformational enzymes. A major class of carcinogens, polycyclic aromatic hydrocarbons, present in substantial quantities in tobacco smoke, is discussed. The historical background and an overview of the metabolic pathways are given. The epidemiological and biological data in particular on dosimetry of the representative DNA adducts and… CONTINUE READING

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