Biomonitoring of carcinogenic heterocyclic aromatic amines in hair: a validation study.

  title={Biomonitoring of carcinogenic heterocyclic aromatic amines in hair: a validation study.},
  author={Erin E Bessette and I. Wayan W. Yasa and Deborah Dunbar and Lynne Ross Wilkens and Lo{\"i}c Le Marchand and Robert J Turesky},
  journal={Chemical research in toxicology},
  volume={22 8},
A facile method was established to measure heterocyclic aromatic amines (HAAs) accumulated in human hair and rodent fur. The samples were digested by base hydrolysis, and the liberated HAAs were isolated by tandem solvent/solid-phase extraction. Quantification was done by liquid chromatography/tandem mass spectrometry, using a triple stage quadrupole mass spectrometer in the selected reaction monitoring mode. In a pilot study of 12 human volunteers, 2-amino-1-methyl-6-phenylimidazo[4,5-b… CONTINUE READING


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