Biomolecular ligands screening using radiation damping difference WaterLOGSY spectroscopy.

@article{Sun2013BiomolecularLS,
  title={Biomolecular ligands screening using radiation damping difference WaterLOGSY spectroscopy.},
  author={Peng Sun and Xianwang Jiang and Bin Jiang and Xu Jin Zhang and Maili Liu},
  journal={Journal of biomolecular NMR},
  year={2013},
  volume={56 3},
  pages={285-90}
}
Water-ligand observed via gradient spectroscopy (WaterLOGSY) is a widely used nuclear magnetic resonance method for ligand screening. The crucial procedure for the effectiveness of WaterLOGSY is selective excitation of the water resonance. The selective excitation is conventionally achieved by using long selective pulse, which causes partial saturation of the water magnetization leading to reduction of sensitivity, in addition to time consuming and error prone. Therefore, many improvements have… CONTINUE READING