Biomolecular interactions modulate macromolecular structure and dynamics in atomistic model of a bacterial cytoplasm

@inproceedings{Yu2016BiomolecularIM,
  title={Biomolecular interactions modulate macromolecular structure and dynamics in atomistic model of a bacterial cytoplasm},
  author={Isseki Yu and Takaharu Mori and Tadashi Ando and Ryuhei Harada and Jaewoon Jung and Yuji Sugita and Michael Feig},
  booktitle={eLife},
  year={2016}
}
Biological macromolecules function in highly crowded cellular environments. The structure and dynamics of proteins and nucleic acids are well characterized in vitro, but in vivo crowding effects remain unclear. Using molecular dynamics simulations of a comprehensive atomistic model cytoplasm we found that protein-protein interactions may destabilize native protein structures, whereas metabolite interactions may induce more compact states due to electrostatic screening. Protein-protein… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1,077 times over the past 90 days. VIEW TWEETS