Biomineralization and size control of stable calcium phosphate core-protein shell nanoparticles: potential for vaccine applications.

@article{Chiu2012BiomineralizationAS,
  title={Biomineralization and size control of stable calcium phosphate core-protein shell nanoparticles: potential for vaccine applications.},
  author={David Chiu and Weibin Zhou and Sathana Kitayaporn and Daniel T. Schwartz and Kaja Murali-Krishna and Terrance J Kavanagh and François Baneyx},
  journal={Bioconjugate chemistry},
  year={2012},
  volume={23 3},
  pages={610-7}
}
Calcium phosphate (CaP) polymorphs are nontoxic, biocompatible and hold promise in applications ranging from hard tissue regeneration to drug delivery and vaccine design. Yet, simple and robust routes for the synthesis of protein-coated CaP nanoparticles in the sub-100 nm size range remain elusive. Here, we used cell surface display to identify disulfide-constrained CaP binding peptides that, when inserted within the active site loop of Escherichia coli thioredoxin 1 (TrxA), readily and… CONTINUE READING
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