Biomimetic total synthesis of (-)-erinacine E.

  title={Biomimetic total synthesis of (-)-erinacine E.},
  author={Hideaki Watanabe and Masahisa Nakada},
  journal={Journal of the American Chemical Society},
  volume={130 4},
In 1996, (-)-erinacine E ( 1) (Figure 1) was reported to be a strong stimulator of nerve growth factor (NGF) synthesis from the mycelia ofHericium erinaceumwhose fruiting bodies have been known as Chinese medicine or food. 1 Two years later, a Pfizer research group isolated 1 from a different source, the fermentation broth ofHericium ramosumCL24240, and disclosed that 1 was a potent, highly selectiveκ-opioid receptor agonist. 2 

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