Biomimetic synthesis and optimization of cyclic peptide antibiotics

@article{Kohli2002BiomimeticSA,
  title={Biomimetic synthesis and optimization of cyclic peptide antibiotics},
  author={R. M. Kohli and C. Walsh and M. Burkart},
  journal={Nature},
  year={2002},
  volume={418},
  pages={658-661}
}
Molecules in nature are often brought to a bioactive conformation by ring formation (macrocyclization). A recurrent theme in the enzymatic synthesis of macrocyclic compounds by non-ribosomal and polyketide synthetases is the tethering of activated linear intermediates through thioester linkages to carrier proteins, in a natural analogy to solid-phase synthesis. A terminal thioesterase domain of the synthetase catalyses release from the tether and cyclization. Here we show that an isolated… Expand
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TLDR
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