Biomimetic sulphated alginate hydrogels suppress IL-1β-induced inflammatory responses in human chondrocytes.

@article{Arlov2017BiomimeticSA,
  title={Biomimetic sulphated alginate hydrogels suppress IL-1β-induced inflammatory responses in human chondrocytes.},
  author={\Oystein Arlov and Matthias R Steinwachs and Gudmund Skj{\aa}k-Br{\ae}k and Marcy Zenobi-Wong},
  journal={European cells & materials},
  year={2017},
  volume={33},
  pages={76-89}
}
Loss of articular cartilage from ageing, injury or degenerative disease is commonly associated with inflammation, causing pain and accelerating degradation of the cartilage matrix. Sulphated glycosaminoglycans (GAGs) are involved in the regulation of immune responses in vivo, and analogous polysaccharides are currently being evaluated for tissue engineering matrices to form a biomimetic environment promoting tissue growth while suppressing inflammatory and catabolic activities. Here, we… CONTINUE READING