• Corpus ID: 40220328

Biomimetic recognition and immunochemical assay of ligand binding to collagen.

  title={Biomimetic recognition and immunochemical assay of ligand binding to collagen.},
  author={Jayalakshmi Vaidyanathan and Kasinathan Chinnaswamy and Tritala K Vaidyanathan},
  journal={The journal of adhesive dentistry},
  volume={5 1},
PURPOSE The objectives of this investigation were to analyze the adhesive interactions between type 1 collagen and two hydrophilic monomer primers (ligands) for dentin bonding through computer modeling and a novel immunochemical binding assay method. MATERIALS AND METHODS The hydrophilic monomers studied included 2-hydroxyethyl methacrylate (HEMA) and 2-acryloyloxyethyl phosphate (PA). For computer modeling studies, a triple helical model structure of collagen fibril extracted from a public… 

Computer simulated screening of dentin bonding primer monomers through analysis of their chemical functions and their spatial 3D alignment.

The results elegantly demonstrate that an indirect approach used to identify pharmacaphore models from adhesive ligands without a target may be a simple and viable approach to assess their intermolecular interactions with an intended target.

Recent advances in the theory and mechanism of adhesive resin bonding to dentin: a critical review.

This review analyzes current theoretical and mechanism-related issues of interest in adhesive resin bonding to dentin, and outlines the continuing problems that need to be overcome in the future.

In vitro regulation of single collagen fibril length by buffer compositions and temperature.

Single fibrils formed in SP buffer were found to have greater average length than those formed in PBS buffer, and at the same temperature, the average lengths of single fibril lengths differed significantly between PBS and SP buffers.

The effect of cationic polymer treatment on dye staining and on the adhesion of charged particles to dentin.

Photocrosslinkable Gelatin Hydrogels Modulate the Production of the Major Pro-inflammatory Cytokine, TNF-α, by Human Mononuclear Cells

This work investigated the ability of human mononuclear cells to mount inflammatory responses in the context of a GelMA hydrogel platform and found tumor necrosis factor-α expression was suppressed in GelMA culture conditions.

Effect of anions on type I collagen fibrillogenesis in aqueous solution

  • J. XingL. YangY. Li
  • Chemistry
    2011 International Symposium on Water Resource and Environmental Protection
  • 2011
Collagen is the most abundant protein in the human body. Fibrillogenesis is one of important aspect of collagen. In vitro reconstitution of collagen fibrils is triggered simply by warming,

Development of biomimetic platforms to investigate the influence of the extra-cellular environment on immunological responses

The development and characterisation of tissue-engineered platforms for immune cell culture which incorporate the ECM and shear flow are described to apply these platforms for the study of the effect of the extra-cellular environment on dendritic cells and their interactions with T cells in the context of immunological stimulation.

Water Concentration in Self-etching Primers Affects their Aggressiveness and Bonding Efficacy to Dentin

Water is required to ionize acid resin monomers for demineralization of tooth substrates and a balance must be achieved to provide sufficient water for adequate ionization of the acidic monomers, without lowering the resin concentration too much, to optimize their bonding efficacy to dentin.