Biomimetic nanostructures: creating a high-affinity zinc-binding site in a folded nonbiological polymer.

@article{Lee2008BiomimeticNC,
  title={Biomimetic nanostructures: creating a high-affinity zinc-binding site in a folded nonbiological polymer.},
  author={Byoung-Chul Lee and Tammy K Chu and Ken A. Dill and Ronald N. Zuckermann},
  journal={Journal of the American Chemical Society},
  year={2008},
  volume={130 27},
  pages={8847-55}
}
One of the long-term goals in developing advanced biomaterials is to generate protein-like nanostructures and functions from a completely nonnatural polymer. Toward that end, we introduced a high-affinity zinc-binding function into a peptoid (N-substituted glycine polymer) two-helix bundle. Borrowing from well-understood zinc-binding motifs in proteins, thiol and imidazole moieties were positioned within the peptoid such that both helices must align in close proximity to form a binding site. We… CONTINUE READING