Biomedical accelerator mass spectrometry: recent applications in metabolism and pharmacokinetics

@article{Lappin2008BiomedicalAM,
  title={Biomedical accelerator mass spectrometry: recent applications in metabolism and pharmacokinetics},
  author={G. Lappin and L. Stevens},
  journal={Expert Opinion on Drug Metabolism \& Toxicology},
  year={2008},
  volume={4},
  pages={1021 - 1033}
}
Background: Accelerator mass spectrometry (AMS) is a sensitive isotope ratio technique used in drug development that allows for small levels of 14C-drug to be administered to humans, thereby removing regulatory hurdles associated with radiotracer studies. AMS uses innovative study designs to obtain pharmacokinetic and metabolism data. Objective: This review addresses the metabolism and pharmacokinetics relevant to cases where therapeutic drug concentrations are achieved in humans. Methods: The… Expand
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