Biomedical Applications of Nanodiamonds: An Overview.

  title={Biomedical Applications of Nanodiamonds: An Overview.},
  author={Daniele Passeri and Federica Rinaldi and Cinzia Ingallina and Maria Carafa and Mara Rossi and Maria Letizia Terranova and Carlotta Marianecci},
  journal={Journal of nanoscience and nanotechnology},
  volume={15 2},
Nanodiamonds are a novel class of nanomaterials which have raised much attention for application in biomedical field, as they combine the possibility of being produced on large scale using relatively inexpensive synthetic processes, of being fluorescent as a consequence of the presence of nitrogen vacancies, of having their surfaces functionalized, and of having good biocompatibility. Among other applications, we mainly focus on drug delivery, including cell interaction, targeting, cancer… 

Figures and Tables from this paper

Biomedical applications of nanodiamond (Review).
This review covers the recent progress as well as general trends in biomedical applications of nanodiamond, and underlines the importance of purification, characterization, and rational modification of this nanomaterial when designing nanod diamond based theranostic platforms.
Production, surface modification and biomedical applications of nanodiamonds: A sparkling tool for theranostics.
Surface Modification of Fluorescent Nanodiamonds for Biological Applications
This review provides an overview of nanodiamond surface functionalization methods including homogeneous surface termination approaches (hydrogenation, halogenation, amination, oxidation, and reduction), in addition to covalent and non-covalent surface modification with different functional moieties.
Multifunctional nanodiamonds as emerging platforms for cancer treatment, and targeted delivery of genetic factors and protein medications—a review
A comprehensive discussion on nanodiamonds for biomedical applications, including cancer treatment, delivery of genetic factors, and protein medication is provided, and future directions and problems in engineering, medicine, and biotechnology research for NDs are outlined.
Predicting the impact of structural diversity on the performance of nanodiamond drug carriers.
In this review a series of computational and statistical studies will be summarised and reviewed, to characterise the relationship between chemical complexity, structural diversity and the reactive performance of nanodiamond drug carriers.
Role of Nanodiamonds in Drug Delivery and Stem Cell Therapy
NDs based drug delivery systems may form the basis for the development of effective novel drug delivery vehicles with salient features that may facilitate their utility in fluorescence imaging, target specificity and sustainedrelease.
Carbon Quantum Dots: In vitro and in vivo Studies on Biocompatibility and Biointeractions for Optical Imaging
It is demonstrated that the CQDs have an excellent biocompatibility and can be used as efficient optical nanoprobes for cell tracking and biomedical labeling except for L929 and PC-3M cells.
Surface Modified Multifunctional and Stimuli Responsive Nanoparticles for Drug Targeting: Current Status and Uses
This review aims to summarize the “state of the art” of drug delivery carriers in nanosize, paying attention to their surface functionalization with ligands and other small or polymeric compounds so as to upgrade active and passive targeting, different release patterns as well as cell targeting and stimuli responsibility.
Fructose-Coated Nanodiamonds: Promising Platforms for Treatment of Human Breast Cancer.
The massive cell death after 8-day incubation with Poly(1-O-MAFru)62-ND-Dox demonstrates that glycopolymer-coated nanodiamonds can be promising platforms for breast cancer therapy.


Ultrananocrystalline Diamond: Synthesis, Properties, and Applications
"Ultrananocrystalline Diamond: Syntheses, Properties, and Applications" is a unique practical reference handbook that brings together the basic science of nanoscale carbon structures, particularly
A new language, Opt, is proposed for writing these objective functions over image- or graph-structured unknowns concisely and at a high level and automatically transforms these specifications into state-of-the-art GPU solvers based on Gauss-Newton or Levenberg-Marquardt methods.
Nanodiamonds: Applications in Biology and Medicine, edited by D
  • 2010
Nanoparticle conjugates for use as active principles in pharmaceuticals and cosmetics,
  • ES 2376937
  • 2012
Preparation of antitumor fluorescent diamond nanoparticleadriamycin composite for target drug delivery
  • J . Mater . Chem . B
  • 2014
Preparation of antitumor fluorescent diamond nanoparticleadriamycin composite for target drug delivery,” CN 102716137 A 20121010 (2012)
  • J. Nanosci. Nanotechnol. 15, 972–988,
  • 2015
Use of nanodiamands for generating therapeutic free radicals under irradiation
  • FR 2993180
  • 2014
System for delivering biologically active agents into an organism and method for producing said system
  • WO 2013015704
  • 2013
3, 201 (1993)
  • 986 J. Nanosci. Nanotechnol. 15, 972–988,
  • 2015
and S
  • D. Glassman, Spine (Phila Pa
  • 1976