Biomedical Applications of Lumazine Synthase.

@article{Wei2018BiomedicalAO,
  title={Biomedical Applications of Lumazine Synthase.},
  author={Yangjie Wei and Prashant Kumar and Newton Wahome and Nicholas J. Mantis and C. Russell Middaugh},
  journal={Journal of pharmaceutical sciences},
  year={2018},
  volume={107 9},
  pages={
          2283-2296
        }
}
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Structural studies of lumazine synthases : Thermostability, catalytic mechanism and molecular assembly
Riboflavin, also known as vitamin B2, is biosynthesized in plants, bacteria, archaea and fungi. The primary biological function of riboflavin is related to its existence as a component of the two
Sequence determinants of quaternary structure in lumazine synthase.
TLDR
A combined analysis that includes sequence-structure and evolutionary studies to find the sequence determinants of the different quaternary assemblies of the lumazine synthase family found eight sequence sites that would be the most important icosahedral sequence determinant.
High Order Quaternary Arrangement Confers Increased Structural Stability to Brucella sp. Lumazine Synthase*
TLDR
The present work demonstrates by means of solution light scattering and x-ray structural analyses that BLS assembles as a very stable dimer of pentamers, representing a third category of quaternary assembly for lumazine synthases, and describes by spectroscopic studies the thermodynamic stability of this oligomeric protein.
Evaluation of lumazine synthase from Bacillus anthracis as a presentation platform for polyvalent antigen display
TLDR
Lumazine synthase (LS), an icosahedral symmetry capsid derived from Bacillus anthracis, is used as a scaffold to present 60 copies of a linear B cell epitope from the ricin toxin fused to the C terminus of LS via four different linkers, and formaldehyde crosslinking considerably improved protein thermal stability with only minor impact on protein conformation.
Lumazine Synthase from Candida albicans as an Anti-fungal Target Enzyme
TLDR
The crystal structure of lumazine synthase from Candida albicans was solved by molecular replacement and refined at 2.5-Å resolution and revealed high affinity for all four compounds with binding constants in the micromolar range.
Structural and thermodynamic insights into the binding mode of five novel inhibitors of lumazine synthase from Mycobacterium tuberculosis
TLDR
The ribitylpurinetrione compounds with C4–C5 alkylphosphate chains with high affinity and specificity to lumazine synthase are proposed as most promising leads for further development of therapeutic drugs against M. tuberculosis.
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