Biomechanics of cardiac electromechanical coupling and mechanoelectric feedback.

Abstract

Cardiac mechanical contraction is triggered by electrical activation via an intracellular calcium-dependent process known as excitation-contraction coupling. Dysregulation of cardiac myocyte intracellular calcium handling is a common feature of heart failure. At the organ scale, electrical dyssynchrony leads to mechanical alterations and exacerbates pump… (More)
DOI: 10.1115/1.4026221

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