Biomechanics of Schlemm's canal endothelial cells: influence on F-actin architecture.

@article{Ethier2004BiomechanicsOS,
  title={Biomechanics of Schlemm's canal endothelial cells: influence on F-actin architecture.},
  author={C. Ross Ethier and A. Thomas Read and Darren W-H Chan},
  journal={Biophysical journal},
  year={2004},
  volume={87 4},
  pages={2828-37}
}
Aqueous humor drains from the eye through Schlemm's canal, a small endothelial-lined collecting duct. Schlemm's canal endothelial cells may be important in controlling the pressure within the eye (and hence are of interest in glaucoma), and are subject to an unusual combination of shear stress and a basal-to-apical pressure gradient. We sought to characterize this biomechanical environment and determine its effects on F-actin architecture in situ. A theoretical model of flow in Schlemm's canal… CONTINUE READING