Biomechanical strain causes maladaptive gene regulation, contributing to Alport glomerular disease.

  title={Biomechanical strain causes maladaptive gene regulation, contributing to Alport glomerular disease.},
  author={Daniel T. Meehan and Duane C. Delimont and Linda Cheung and Marisa Zallocchi and Steven C. Sansom and J David Holzclaw and Velidi H Rao and Dominic Cosgrove},
  journal={Kidney international},
  volume={76 9},
Patients with Alport's syndrome develop a number of pro-inflammatory cytokine and matrix metalloproteinase (MMP) abnormalities that contribute to progressive renal failure. Changes in the composition and structure of the glomerular basement membranes likely alter the biomechanics of cell adhesion and signaling in these patients. To test if enhanced strain on the capillary tuft due to these structural changes contributes to altered gene regulation, we subjected cultured podocytes to cyclic… CONTINUE READING


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