Biomechanical regulation of human monocyte/macrophage molecular function.

@article{Yang2000BiomechanicalRO,
  title={Biomechanical regulation of human monocyte/macrophage molecular function.},
  author={Jincheng Yang and Hideo Sakamoto and Elizabeth Chang Xu and Richard T Lee},
  journal={The American journal of pathology},
  year={2000},
  volume={156 5},
  pages={
          1797-804
        }
}
When the monocyte infiltrates a tissue, adhesion to the extracellular matrix provides structural anchors, and the cell may be deformed through these attachments. To test the hypothesis that human monocytes/macrophages are mechanically responsive, we studied the effects of small cyclic mechanical deformations on cultured human monocytes/macrophages. When monocytes/macrophages were subjected to 4% strain at 1 Hz for 24 hours, neither matrix metalloproteinase (MMP)-1 nor MMP-3 was induced; however… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 34 CITATIONS

Similar Papers

Loading similar papers…