Biomechanical regulation of blood vessel growth during tissue vascularization

@article{Kilarski2009BiomechanicalRO,
  title={Biomechanical regulation of blood vessel growth during tissue vascularization},
  author={Witold W Kilarski and Branka Samolov and Ludvig Petersson and Anders Kvanta and P{\"a}r Gerwins},
  journal={Nature Medicine},
  year={2009},
  volume={15},
  pages={657-664}
}
Formation of new vessels in granulation tissue during wound healing has been assumed to occur solely through sprouting angiogenesis. In contrast, we show here that neovascularization can be accomplished by nonangiogenic expansion of preexisting vessels. Using neovascularization models based on the chick chorioallantoic membrane and the healing mouse cornea, we found that tissue tension generated by activated fibroblasts or myofibroblasts during wound contraction mediated and directed… CONTINUE READING
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