Biomechanical properties of intermediate filaments: from tissues to single filaments and back.

Abstract

The animal cell cytoskeleton consists of three interconnected filament systems: actin-containing microfilaments (MFs), microtubules (MTs), and the lesser known intermediate filaments (IFs). All IF proteins share a common tripartite domain structure and the ability to assemble into 8-12 nm wide filaments. Electron microscopy data suggest that IFs are built according to a completely different plan from that of MFs and MTs. IFs are known to impart mechanical stability to cells and tissues but, until recently, the biomechanical properties of single IFs were unknown. However, with the discovery of naturally occurring micrometer-wide IF bundles and the development of new methodologies to mechanically probe single filaments, it is now possible to propose a more unified view of IF biomechanics. Unlike MFs and MTs, single IFs can now be described as flexible, extensible and tough, which has important implications for our understanding of cell and tissue mechanics. Furthermore, the molecular mechanisms at play when IFs are deformed point toward a pivotal role for them in mechanotransduction.

5 Figures and Tables

05010015020072008200920102011201220132014201520162017
Citations per Year

368 Citations

Semantic Scholar estimates that this publication has 368 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Kreplak2007BiomechanicalPO, title={Biomechanical properties of intermediate filaments: from tissues to single filaments and back.}, author={Laurent Kreplak and Douglas S Fudge}, journal={BioEssays : news and reviews in molecular, cellular and developmental biology}, year={2007}, volume={29 1}, pages={26-35} }