Biomechanical properties of intermediate filaments: from tissues to single filaments and back

  title={Biomechanical properties of intermediate filaments: from tissues to single filaments and back},
  author={L. Kreplak and D. Fudge},
  • L. Kreplak, D. Fudge
  • Published 2007
  • Biology, Medicine
  • BioEssays
  • The animal cell cytoskeleton consists of three interconnected filament systems: actin‐containing microfilaments (MFs), microtubules (MTs), and the lesser known intermediate filaments (IFs). All IF proteins share a common tripartite domain structure and the ability to assemble into 8–12 nm wide filaments. Electron microscopy data suggest that IFs are built according to a completely different plan from that of MFs and MTs. IFs are known to impart mechanical stability to cells and tissues but… CONTINUE READING
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