Biomechanical Thresholds Regulate Inflammation through the NF-κB Pathway: Experiments and Modeling

@article{Nam2009BiomechanicalTR,
  title={Biomechanical Thresholds Regulate Inflammation through the NF-κB Pathway: Experiments and Modeling},
  author={Jin Nam and Baltazar D. Aguda and Bj{\"o}rn Rath and Sudha Agarwal},
  journal={PLoS ONE},
  year={2009},
  volume={4},
  pages={1737 - 1745}
}
BACKGROUND During normal physical activities cartilage experiences dynamic compressive forces that are essential to maintain cartilage integrity. However, at non-physiologic levels these signals can induce inflammation and initiate cartilage destruction. Here, by examining the pro-inflammatory signaling networks, we developed a mathematical model to show the magnitude-dependent regulation of chondrocytic responses by compressive forces. METHODOLOGY/PRINCIPAL FINDINGS Chondrocytic cells grown… CONTINUE READING
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