Biomaterials for Nanoparticle Vaccine Delivery Systems

@article{Sahdev2014BiomaterialsFN,
  title={Biomaterials for Nanoparticle Vaccine Delivery Systems},
  author={Preety Sahdev and Lukasz J. Ochyl and James J Moon},
  journal={Pharmaceutical Research},
  year={2014},
  volume={31},
  pages={2563-2582}
}
Subunit vaccination benefits from improved safety over attenuated or inactivated vaccines, but their limited capability to elicit long-lasting, concerted cellular and humoral immune responses is a major challenge. Recent studies have demonstrated that antigen delivery via nanoparticle formulations can significantly improve immunogenicity of vaccines due to either intrinsic immunostimulatory properties of the materials or by co-entrapment of molecular adjuvants such as Toll-like receptor… CONTINUE READING

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