Biomaterial particle phagocytosis by bone-resorbing osteoclasts.

@article{Wang1997BiomaterialPP,
  title={Biomaterial particle phagocytosis by bone-resorbing osteoclasts.},
  author={Wilson Q. Wang and David J. Ferguson and Julian M W Quinn and A. Hamish R.W. Simpson and Nicholas A Athanasou},
  journal={The Journal of bone and joint surgery. British volume},
  year={1997},
  volume={79 5},
  pages={
          849-56
        }
}
Abundant implant-derived biomaterial wear particles are generated in aseptic loosening and are deposited in periprosthetic tissues in which they are phagocytosed by mononuclear and multinucleated macrophage-like cells. It has been stated that the multinucleated cells which contain wear particles are not bone-resorbing osteoclasts. To investigate the validity of this claim we isolated human osteoclasts from giant-cell tumours of bone and rat osteoclasts from long bones. These were cultured on… Expand
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