Biomaterial-associated infection of gentamicin-loaded PMMA beads in orthopaedic revision surgery.

@article{Neut2001BiomaterialassociatedIO,
  title={Biomaterial-associated infection of gentamicin-loaded PMMA beads in orthopaedic revision surgery.},
  author={Dani{\"e}lle Neut and Hilbrand van de Belt and Ietse Stokroos and Jim R. van Horn and Henny C van der Mei and Henk J. Busscher},
  journal={The Journal of antimicrobial chemotherapy},
  year={2001},
  volume={47 6},
  pages={885-91}
}
In two-stage orthopaedic revision surgery, high local levels of antibiotics are achieved after removal of an infected prosthesis through temporary implantation of gentamicin-loaded beads. However, despite their antibiotic release, these beads act as a biomaterial surface to which bacteria preferentially adhere, grow and potentially develop antibiotic resistance. Gentamicin-loaded beads were retrieved from 20 patients with prosthesis-related infections. Excised tissue samples were taken for… CONTINUE READING