Biomarkers to Identify the Pathological Basis for Frontotemporal Lobar Degeneration

  title={Biomarkers to Identify the Pathological Basis for Frontotemporal Lobar Degeneration},
  author={Murray Grossman},
  journal={Journal of Molecular Neuroscience},
Recent findings assessing the utility of biomarkers are reviewed that help identify the basis for disease in patients with frontotemporal lobar degeneration (FTLD) spectrum pathology. Biofluid studies identify about 15% of patients with FTLD due to a genetic mutation that is associated with the specific histopathologic features of TDP-43 or a tauopathy. Other genetically based risk factors and targeted proteomic searches of plasma and cerebrospinal fluid have suggested additional markers that… CONTINUE READING


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