Biomarkers predict radiographic progression in early rheumatoid arthritis and perform well compared with traditional markers.

@article{YoungMin2007BiomarkersPR,
  title={Biomarkers predict radiographic progression in early rheumatoid arthritis and perform well compared with traditional markers.},
  author={Steven A. Young-Min and Timothy E Cawston and Nicola J Marshall and David P. Coady and Stephan Christgau and Tore Saxne and Simon Robins and Ian Griffiths},
  journal={Arthritis and rheumatism},
  year={2007},
  volume={56 10},
  pages={3236-47}
}
OBJECTIVE To evaluate the performance of biochemical and traditional markers in predicting radiographic progression in rheumatoid arthritis (RA). METHODS One hundred thirty-two patients with early RA were treated with nonbiologic therapies for 2 years and studied longitudinally. Genomic DNA was analyzed for presence of the shared epitope. Levels of matrix metalloproteinases (matrix metalloproteinase 1 [MMP-1], MMP-13, and MMP-3), tissue inhibitor of metalloproteinases 1 (TIMP-1), and… CONTINUE READING

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