Biomarkers of oxidative stress study VI. Endogenous plasma antioxidants fail as useful biomarkers of endotoxin-induced oxidative stress.

@article{Kadiiska2015BiomarkersOO,
  title={Biomarkers of oxidative stress study VI. Endogenous plasma antioxidants fail as useful biomarkers of endotoxin-induced oxidative stress.},
  author={Maria B. Kadiiska and Shyamal D. Peddada and R. A. Herbert and Samar Basu and Kenneth Hensley and D. H. P. Jones and Gary E. Hatch and Ronald Paul Mason},
  journal={Free radical biology & medicine},
  year={2015},
  volume={81},
  pages={100-6}
}
This is the newest report in a series of publications aiming to identify a blood-based antioxidant biomarker that could serve as an in vivo indicator of oxidative stress. The goal of the study was to test whether acutely exposing Göttingen mini pigs to the endotoxin lipopolysaccharide (LPS) results in a loss of antioxidants from plasma. We set as a criterion that a significant effect should be measured in plasma and seen at both doses and at more than one time point. Animals were injected with… CONTINUE READING