Biomarkers of multiorgan injury in a preclinical model of exertional heat stroke.
@article{King2015BiomarkersOM, title={Biomarkers of multiorgan injury in a preclinical model of exertional heat stroke.}, author={Michelle A. King and Lisa R Leon and Danielle L. Mustico and Joel M. Haines and Thomas L Clanton}, journal={Journal of applied physiology}, year={2015}, volume={118 10}, pages={ 1207-20 } }
It is likely that the pathophysiology of exertional heat stroke (EHS) differs from passive heat stroke (PHS), but this has been difficult to verify experimentally. C57Bl/6 mice were instrumented with temperature transponders and underwent 3 wk of training using voluntary and forced running wheels. An EHS group was exposed to environmental temperatures (Tenv) of 37.5, 38.5, or 39.5°C at either 30, 50, or 90% relative humidities (RH) while exercising on a forced running wheel. Results were…
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References
SHOWING 1-10 OF 77 REFERENCES
Cardiovascular and thermoregulatory biomarkers of heat stroke severity in a conscious rat model.
- BiologyJournal of applied physiology
- 2014
Novel biomarkers that predict HS severity and organ damage during acute recovery that could provide clinical significance for identifying key biomarkers of HS pathogenesis are identified.
Heat stress induces a biphasic thermoregulatory response in mice.
- BiologyAmerican journal of physiology. Regulatory, integrative and comparative physiology
- 2005
It is shown that recovery from acute heat stress is associated with prolonged hypothermia followed by an elevation in daytime T(c) that is dependent on T(a).
Rat model of acute heatstroke mortality.
- BiologyJournal of applied physiology: respiratory, environmental and exercise physiology
- 1977
Results indicate that both the incidence of mortality and the survival time can be predicted from the severity of core heating, work-related factors contribute to an increased rate of heatstroke death at low thermal loads, and retrospectively, both heat-sensitive and heat-resistant groups were identified.
Role of physical effort in the etiology of rat heatstroke injury and mortality.
- BiologyJournal of applied physiology: respiratory, environmental and exercise physiology
- 1978
The results suggest a direct role of physical effort in causing heatstroke injury and mortality in rats, and bore a striking resemblance to curves reflecting heat- and/or work-induced mortality in humans.
Diagnostic significance of selected serum enzymes in a rat heatstroke model.
- MedicineJournal of applied physiology: respiratory, environmental and exercise physiology
- 1979
Each of the three experimental conditions produced a unique pattern of serum enzyme activity that would appear useful in diagnosing a variety of heat- and/or work-induced disorders.
Acute exercises induce disorders of the gastrointestinal integrity in a murine model
- Medicine, BiologyEuropean Journal of Applied Physiology
- 2013
There is evidence that after intense endurance exercise repair processes occur in small intestinal epithelial cells, which affect permeability, Gt, and Isc, and the formation of lamellipodia to close the “leaky” tight junctions might be an underlying mechanism.
Mechanisms of circulatory and intestinal barrier dysfunction during whole body hyperthermia.
- MedicineAmerican journal of physiology. Heart and circulatory physiology
- 2001
It is concluded that hyperthermia stimulates xanthine oxidase production of reactive oxygen species that activate metals and limit heat tolerance by promoting circulatory and intestinal barrier dysfunction and intact NOS activity is required for normal stress tolerance, whereas overproduction ofNO may contribute to the nonprogrammed splanchnic dilation that precedes vascular collapse with heat stroke.
Thermoregulatory, behavioral, and metabolic responses to heatstroke in a conscious mouse model.
- BiologyAmerican journal of physiology. Regulatory, integrative and comparative physiology
- 2010
T(c) responses of mild and severe HS mice suggest a need for reinterpretation of the mechanisms of thermoregulatory control during recovery, and decreases and increases were associated with behavioral and autonomic thermoeffectors that suggest HS elicits anapyrexia and fever, respectively.
Effects of exercise in the heat on predisposition to heatstroke.
- MedicineMedicine and science in sports
- 1979
A new hypothesis combining the essential features of both direct thermal injury and cardiovascular origins of heatstroke pathophysiology may be necessary.