Biomarkers of multiorgan injury in a preclinical model of exertional heat stroke.

@article{King2015BiomarkersOM,
  title={Biomarkers of multiorgan injury in a preclinical model of exertional heat stroke.},
  author={Michelle A. King and Lisa R Leon and Danielle L. Mustico and Joel M. Haines and Thomas L Clanton},
  journal={Journal of applied physiology},
  year={2015},
  volume={118 10},
  pages={
          1207-20
        }
}
It is likely that the pathophysiology of exertional heat stroke (EHS) differs from passive heat stroke (PHS), but this has been difficult to verify experimentally. C57Bl/6 mice were instrumented with temperature transponders and underwent 3 wk of training using voluntary and forced running wheels. An EHS group was exposed to environmental temperatures (Tenv) of 37.5, 38.5, or 39.5°C at either 30, 50, or 90% relative humidities (RH) while exercising on a forced running wheel. Results were… 
View on PubMed
jap.physiology.org
29 Citations
Highly Influential Citations
1
Background Citations
9
Methods Citations
6
Results Citations
1

Figures and Tables from this paper

29 Citations

Prevention of Organ Injury in Exertional Heat Stroke: Preclinical Evaluation of a New Class of NSAIDs
TLDR
These results may reflect, in part, hypoglycemia seen following exercise in the heat but are also consistent with transient organ dysfunction, specifically in the liver and/or pancreas (suppression of insulin secretion without compensating glucagon response).
Effects of Ibuprofen during Exertional Heat Stroke in Mice
TLDR
Oral IBU at pharmacologically effective doses does not pose additional risks of heat stroke, does not reduce exercise performance, and does not contribute further to intestinal injury, though this could have been masked by significant gut injury induced by EHS alone.
Pretreatment with indomethacin results in increased heat stroke severity during recovery in a rodent model of heat stroke.
TLDR
It is shown here that a small, single dose of the NSAID indomethacin before heat stroke has a dramatic and highly damaging effect on the gut, which ultimately leads to increased systemic morbidity.
Controversies in Exertional Heat Stroke Diagnosis, Prevention and Treatment.
TLDR
This review examines the following eight controversies about reliance on core temperature for diagnosing and assessing severity of exertional heat stroke and presents and discusses the origins and the evidence for each controversy and proposes next steps to resolve the misconception.
Pathophysiology of heatstroke in dogs – revisited
TLDR
The pathophysiology of canine heatstroke from a veterinarian's point of view is discussed, integrating new and old studies and knowledge.
Use of the heat tolerance test to assess recovery from exertional heat stroke
TLDR
An overview of the HTT and the controversy of this test is provided with respect to assessment criteria, applicability to tasks involving high metabolic workloads, and the lack of follow-up analyses to determine its accuracy for determining recovery in order to diminish the likelihood of a second EHS occurrence.
Hospitalized dogs recovery from naturally occurring heatstroke; does serum heat shock protein 72 can provide prognostic biomarker?
TLDR
Results suggest that eHSP72 level profile may be predictive of survival in dogs diagnosed with environmental or exertional heatstroke and tested for biomarkers of organ damage and coagulation parameters.
Optimization of a Rhabdomyolysis Model in Mice With Exertional Heat Stroke Mouse Model of EHS-Rhabdomyolysis
TLDR
Improvements are made to a stable EHS-induced RM animal model that accurately reflects the clinical characteristics of EHS patients and provides an objective animal model for further study of the pathogenesis of RM.
Delayed metabolic dysfunction in myocardium following exertional heat stroke in mice
TLDR
It is concluded that exposure to EHS in female mice has the capacity to cause delayed metabolic disorders in the heart that could influence long‐term health.
The Gastrointestinal Exertional Heat Stroke Paradigm: Pathophysiology, Assessment, Severity, Aetiology and Nutritional Countermeasures
Exertional heat stroke (EHS) is a life-threatening medical condition involving thermoregulatory failure and is the most severe condition along a continuum of heat-related illnesses. Current EHS…
...
...

References

SHOWING 1-10 OF 77 REFERENCES
Cardiovascular and thermoregulatory biomarkers of heat stroke severity in a conscious rat model.
TLDR
Novel biomarkers that predict HS severity and organ damage during acute recovery that could provide clinical significance for identifying key biomarkers of HS pathogenesis are identified.
Heat stress induces a biphasic thermoregulatory response in mice.
TLDR
It is shown that recovery from acute heat stress is associated with prolonged hypothermia followed by an elevation in daytime T(c) that is dependent on T(a).
Rat model of acute heatstroke mortality.
TLDR
Results indicate that both the incidence of mortality and the survival time can be predicted from the severity of core heating, work-related factors contribute to an increased rate of heatstroke death at low thermal loads, and retrospectively, both heat-sensitive and heat-resistant groups were identified.
Role of physical effort in the etiology of rat heatstroke injury and mortality.
TLDR
The results suggest a direct role of physical effort in causing heatstroke injury and mortality in rats, and bore a striking resemblance to curves reflecting heat- and/or work-induced mortality in humans.
Diagnostic significance of selected serum enzymes in a rat heatstroke model.
  • R. Hubbard, R. Criss, M. Mager
  • Medicine
    Journal of applied physiology: respiratory, environmental and exercise physiology
  • 1979
TLDR
Each of the three experimental conditions produced a unique pattern of serum enzyme activity that would appear useful in diagnosing a variety of heat- and/or work-induced disorders.
Heat stroke and cytokines.
  • L. Leon
  • Biology
    Progress in brain research
  • 2007
Acute exercises induce disorders of the gastrointestinal integrity in a murine model
TLDR
There is evidence that after intense endurance exercise repair processes occur in small intestinal epithelial cells, which affect permeability, Gt, and Isc, and the formation of lamellipodia to close the “leaky” tight junctions might be an underlying mechanism.
Mechanisms of circulatory and intestinal barrier dysfunction during whole body hyperthermia.
TLDR
It is concluded that hyperthermia stimulates xanthine oxidase production of reactive oxygen species that activate metals and limit heat tolerance by promoting circulatory and intestinal barrier dysfunction and intact NOS activity is required for normal stress tolerance, whereas overproduction ofNO may contribute to the nonprogrammed splanchnic dilation that precedes vascular collapse with heat stroke.
Thermoregulatory, behavioral, and metabolic responses to heatstroke in a conscious mouse model.
TLDR
T(c) responses of mild and severe HS mice suggest a need for reinterpretation of the mechanisms of thermoregulatory control during recovery, and decreases and increases were associated with behavioral and autonomic thermoeffectors that suggest HS elicits anapyrexia and fever, respectively.
Effects of exercise in the heat on predisposition to heatstroke.
  • R. Hubbard
  • Medicine
    Medicine and science in sports
  • 1979
TLDR
A new hypothesis combining the essential features of both direct thermal injury and cardiovascular origins of heatstroke pathophysiology may be necessary.
...
...