Biomarkers of multiorgan injury in a preclinical model of exertional heat stroke.

@article{King2015BiomarkersOM,
  title={Biomarkers of multiorgan injury in a preclinical model of exertional heat stroke.},
  author={Michelle A. King and Lisa R Leon and Danielle L. Mustico and Joel M. Haines and Thomas L Clanton},
  journal={Journal of applied physiology},
  year={2015},
  volume={118 10},
  pages={
          1207-20
        }
}
It is likely that the pathophysiology of exertional heat stroke (EHS) differs from passive heat stroke (PHS), but this has been difficult to verify experimentally. C57Bl/6 mice were instrumented with temperature transponders and underwent 3 wk of training using voluntary and forced running wheels. An EHS group was exposed to environmental temperatures (Tenv) of 37.5, 38.5, or 39.5°C at either 30, 50, or 90% relative humidities (RH) while exercising on a forced running wheel. Results were… 

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