Biomarkers of folate and vitamin B12 are related in blood and cerebrospinal fluid.

@article{Obeid2007BiomarkersOF,
  title={Biomarkers of folate and vitamin B12 are related in blood and cerebrospinal fluid.},
  author={Rima Obeid and Panagiotis Kostopoulos and J Knapp and Mariz Kasoha and George Becker and Klaus Fassbender and Wolfgang Herrmann},
  journal={Clinical chemistry},
  year={2007},
  volume={53 2},
  pages={326-33}
}
BACKGROUND B-vitamins (folate, B(12)) are important micronutrients for brain function and essential cofactors for homocysteine (HCY) metabolism. Increased HCY has been related to neurological and psychiatric disorders. We studied the role of the B-vitamins in HCY metabolism in the brain. METHODS We studied blood and cerebrospinal fluid (CSF) samples from 72 patients who underwent lumbar puncture. We measured HCY, methylmalonic acid (MMA), and cystathionine by gas chromatography-mass… CONTINUE READING