Biomarkers of cardiovascular stress and incident chronic kidney disease.

  title={Biomarkers of cardiovascular stress and incident chronic kidney disease.},
  author={Jennifer E Ho and S. -Y. Hwang and Kai C. Wollert and Martin G. Larson and Susan Wai Yan Cheng and T. Kempf and Ramachandran S. Vasan and James Louis Januzzi and Thomas J. Wang and Caroline Fox},
  journal={Clinical chemistry},
  volume={59 11},
BACKGROUND Growth differentiation factor-15 (GDF-15), soluble ST2 (sST2), and high-sensitivity troponin I (hsTnI) are emerging predictors of adverse clinical outcomes. We examined whether circulating concentrations are related to the development of kidney disease in the community. METHODS Plasma GDF-15, sST2, and hsTnI concentrations were measured in 2614 Framingham Offspring cohort participants (mean age 57 years, 54% women) at the sixth examination cycle (1995-1998). Associations of… CONTINUE READING