Biomarkers of antimony resistance: need for expression analysis of multiple genes to distinguish resistance phenotype in clinical isolates of Leishmania donovani

@article{Kumar2012BiomarkersOA,
  title={Biomarkers of antimony resistance: need for expression analysis of multiple genes to distinguish resistance phenotype in clinical isolates of Leishmania donovani},
  author={Dhiraj Kumar and Raj Vir Singh and Vasundhra Bhandari and Arpita Kulshrestha and Narendra Singh Negi and Poonam Salotra},
  journal={Parasitology Research},
  year={2012},
  volume={111},
  pages={223-230}
}
Resistance to antimony is a major cause of failure to therapy in a large proportion of visceral leishmaniasis cases. Methods to distinguish resistant and sensitive parasite are urgently needed as the standard in vitro intracellular drug susceptibility assays are cumbersome and time consuming. Differential expression profiling studies have led to the identification of several antimony resistance-associated genes; however, their efficacy as a potential biomarker for monitoring antimony resistance… CONTINUE READING
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