Biomarkers of Tuberculosis Severity and Treatment Effect: A Directed Screen of 70 Host Markers in a Randomized Clinical Trial

@inproceedings{Sigal2017BiomarkersOT,
  title={Biomarkers of Tuberculosis Severity and Treatment Effect: A Directed Screen of 70 Host Markers in a Randomized Clinical Trial},
  author={G B Sigal and M. R. Segal and Anu Merin Mathew and Leah Jarlsberg and Martin Wang and Sheila Barbero and Nicole Small and K. Haynesworth and J Luke Davis and Marc H Weiner and W. C. Whitworth and Jon M. Jacobs and Jeffrey S Schorey and D M Lewinsohn and Payam Nahid},
  booktitle={EBioMedicine},
  year={2017}
}
More efficacious treatment regimens are needed for tuberculosis, however, drug development is impeded by a lack of reliable biomarkers of disease severity and of treatment effect. We conducted a directed screen of host biomarkers in participants enrolled in a tuberculosis clinical trial to address this need. Serum samples from 319 protocol-correct, culture-confirmed pulmonary tuberculosis patients treated under direct observation as part of an international, phase 2 trial were screened for 70… CONTINUE READING

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