Biomarkers of Parkinson's disease: present and future.

  title={Biomarkers of Parkinson's disease: present and future.},
  author={Diane Bemis Miller and James P O'Callaghan},
  journal={Metabolism: clinical and experimental},
  volume={64 3 Suppl 1},
Sporadic or idiopathic Parkinson's disease (PD) is an age-related neurodegenerative disorder of unknown origin that ranks only second behind Alzheimer's disease (AD) in prevalence and its consequent social and economic burden. PD neuropathology is characterized by a selective loss of dopaminergic neurons in the substantia nigra pars compacta; however, more widespread involvement of other CNS structures and peripheral tissues now is widely documented. The onset of molecular and cellular… CONTINUE READING