Biomarkers of Attenuation in the Leishmania donovani Centrin Gene Deleted Cell Line—Requirements for Safety in a Live Vaccine Candidate

Abstract

Biomarkers of the attenuated phenotype are needed to develop live attenuated parasites into safe Leishmania vaccines. The centrin-1 gene deleted strain of Leishmania donovani (LdCEN1) shows promise as a vaccine candidate. To identify genes whose expression patterns are indicators of attenuation, the LdCEN1 line was compared to wild type by gene expression… (More)

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