Biomarkers in traumatic brain injury: new concepts

  title={Biomarkers in traumatic brain injury: new concepts},
  author={Dana Slavoaca and Dafin Fior Muresanu and Codruța B{\^i}rle and Olivia Verisezan Rosu and Ioan Chirilă and Iulian Bogdan Dobra and Nicoleta Jemna and Ștefan Strilciuc and P.E. Vos},
  journal={Neurological Sciences},
Traumatic brain injury is a multifaceted condition that encompasses a spectrum of injuries: contusions, axonal injuries in specific brain regions, edema, and hemorrhage. Brain injury determines a broad clinical and disability spectrum due to the implication of various cellular pathways, genetic phenotypes, and environmental factors. It is challenging to predict patient outcomes, to appropriately evaluate the patients, to determine a suitable treatment strategy and rehabilitation program, and to… 
The Current State of Traumatic Brain Injury Biomarker Measurement Methods
This review provides a detailed discussion of devices reported in the academic literature and available on the market that have been designed to measure TBI protein biomarkers in various biofluids and contexts and assess the challenges associated with TBI biomarker measurement devices.
Lipid profiling of brain tissue and blood after traumatic brain injury: A review of human and experimental studies.
There is accumulating evidence in clinical studies in TBI patients and also in experimental models of TBI, that injury triggers a complex pattern of changes in various lipid classes that can be detected in blood, cerebrospinal fluid andAlso in brain tissue.
Prediction of Neurocognitive Outcome after Moderate-Severe Traumatic Brain Injury Using Serum Neuron-Specific Enolase and S100 biomarkers
A significant correlation between NSE at 4h and short and medium-term neuropsychological outcomes is demonstrated, which recommends using this biomarker for selecting patients with a higher risk of cognitive dysfunction.
Serum Biomarkers are Promising Tools to Predict Traumatic Brain Injury Outcome
Traumatic Brain Injury (TBI) is still considered a worldwide leading cause of mortality and morbidity. Within the last decades, different modalities were used to assess severity and outcome including
Electrochemical sensing of blood proteins for mild traumatic brain injury (mTBI) diagnostics and prognostics: towards a point-of-care application†
A critical study on the electrochemical protocols suggested in the literature for detection of mTBI-relevant protein biomarkers is provided, which give an overview of the analytical approaches for transduction element functionalization, review recent technological advances and highlight the key challenges remaining.
The diagnosis and prognostic value of plasma copeptin in traumatic brain injury: a systematic review and meta-analysis
Increased plasma copeptin levels were significantly associated with TBI and had a significant value in diagnosing brain concussion and predicting progressive hemorrhagic injury, and the authors indicate that the copeptin is a potentially promising biomarker for TBI diagnosis and prognosis prediction.
Plasma PrPC and ADAM-10 as novel biomarkers for traumatic brain injury and concussion: a pilot study
The results indicate that PrPC and ADAM10 appear to be useful potential tools for screening of TBI, andADAM10 is closely associated with clinical grade.
Brain Vital Signs in Elite Ice Hockey: Towards Characterizing Objective and Specific Neurophysiological Reference Values for Concussion Management
The findings support the concept that normative physiological data can be used in brain vital signs evaluation in athletes, and should additionally be stratified for age, skill level, and experience.
Network pharmacology to investigate the pharmacological mechanisms of muscone in Xingnaojing injections for the treatment of severe traumatic brain injury
It is shown that muscone and X NJI were similarly effective 168 h after CCI, demonstrating that the muscone in XNJI significantly attenuated neuronal apoptosis through the PI3K/Akt1/NF-kB/P53 pathway.


Biomarkers of Traumatic Brain Injury: Temporal Changes in Body Fluids
Clinical utilization of TBI biomarkers is still at a very early phase despite years of active research, and most biomarkers are rapidly elevated after injury, and they serve as diagnostics tools for some days.
An update on diagnostic and prognostic biomarkers for traumatic brain injury
There are emerging data showing that biofluid-based TBI biomarker tests have the potential to diagnose the presence of TBI of different severities including concussion, and to predict outcome, which could serve as a theranostic tool in facilitating drug development and treatment monitoring.
Biofluid Proteomics and Biomarkers in Traumatic Brain Injury.
In this chapter, the status of biofluid proteomics in TBI is summarized and discussed, with a particular focus on the latest findings.
Traumatic brain injury: classification, models, and markers.
The potential use of molecular markers in detecting and monitoring the progression of TBI is discussed, with particular emphasis on microRNAs as a novel class of molecular modulators of injury and its repair in the neural tissue.
Current Opportunities for Clinical Monitoring of Axonal Pathology in Traumatic Brain Injury
Increased knowledge of the underlying pathophysiology achieved by advanced clinical monitoring raises hope for the development of novel treatment strategies for axonal injury in TBI.
Metabolomics and Biomarker Discovery in Traumatic Brain Injury.
The promising application of metabolomics of readily accessible biofluids for the assessment of TBI as a stand-alone platform or in association with proteomics in the clinical setting is presented.
Systems biology approaches for discovering biomarkers for traumatic brain injury.
Network and pathway analysis is applied to a manually compiled list of 32 protein biomarker candidates from the literature, recover known TBI-related mechanisms, and generate hypothetical new biomarker candidate candidates.
A blood-based biomarker panel to risk-stratify mild traumatic brain injury
Results suggest that a serum based biomarker panel can accurately differentiate patients with complicated mild TBI from those with uncomplicated mild TBO, which could be useful to guide early triage decisions, including the need for further evaluation or admission, especially in those environments in which resources are limited.
Blood Biomarkers for Traumatic Brain Injury: A Quantitative Assessment of Diagnostic and Prognostic Accuracy
The highest-performing biomarkers in each of these categories may provide insight into the pathophysiologies underlying mild and severe TBI, including markers of coagulation and inflammation, structural proteins in the brain, and proteins involved in homeostasis.
Applications of Proteomics in Traumatic Brain Injury: Current Status and Potential Prospects
The efforts to lower the risk of secondary injury and improve outcomes for TBI patients can be ascribed to the process of “squeezing oxygenated blood through a swollen brain”.