Biomarkers in traumatic brain injury: new concepts

@article{Slavoaca2020BiomarkersIT,
  title={Biomarkers in traumatic brain injury: new concepts},
  author={Dana Slavoaca and Dafin Fior Muresanu and Codruța B{\^i}rle and Olivia Verisezan Rosu and Ioan Chirilă and Iulian Bogdan Dobra and Nicoleta Jemna and Ștefan Strilciuc and P.E. Vos},
  journal={Neurological Sciences},
  year={2020},
  pages={1-12}
}
Traumatic brain injury is a multifaceted condition that encompasses a spectrum of injuries: contusions, axonal injuries in specific brain regions, edema, and hemorrhage. Brain injury determines a broad clinical and disability spectrum due to the implication of various cellular pathways, genetic phenotypes, and environmental factors. It is challenging to predict patient outcomes, to appropriately evaluate the patients, to determine a suitable treatment strategy and rehabilitation program, and to… 
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References

SHOWING 1-10 OF 161 REFERENCES
Biomarkers of Traumatic Brain Injury: Temporal Changes in Body Fluids
TLDR
Clinical utilization of TBI biomarkers is still at a very early phase despite years of active research, and most biomarkers are rapidly elevated after injury, and they serve as diagnostics tools for some days.
An update on diagnostic and prognostic biomarkers for traumatic brain injury
TLDR
There are emerging data showing that biofluid-based TBI biomarker tests have the potential to diagnose the presence of TBI of different severities including concussion, and to predict outcome, which could serve as a theranostic tool in facilitating drug development and treatment monitoring.
Biofluid Proteomics and Biomarkers in Traumatic Brain Injury.
TLDR
In this chapter, the status of biofluid proteomics in TBI is summarized and discussed, with a particular focus on the latest findings.
Traumatic brain injury: classification, models, and markers.
TLDR
The potential use of molecular markers in detecting and monitoring the progression of TBI is discussed, with particular emphasis on microRNAs as a novel class of molecular modulators of injury and its repair in the neural tissue.
Current Opportunities for Clinical Monitoring of Axonal Pathology in Traumatic Brain Injury
TLDR
Increased knowledge of the underlying pathophysiology achieved by advanced clinical monitoring raises hope for the development of novel treatment strategies for axonal injury in TBI.
Metabolomics and Biomarker Discovery in Traumatic Brain Injury.
TLDR
The promising application of metabolomics of readily accessible biofluids for the assessment of TBI as a stand-alone platform or in association with proteomics in the clinical setting is presented.
Systems biology approaches for discovering biomarkers for traumatic brain injury.
TLDR
Network and pathway analysis is applied to a manually compiled list of 32 protein biomarker candidates from the literature, recover known TBI-related mechanisms, and generate hypothetical new biomarker candidate candidates.
A blood-based biomarker panel to risk-stratify mild traumatic brain injury
TLDR
Results suggest that a serum based biomarker panel can accurately differentiate patients with complicated mild TBI from those with uncomplicated mild TBO, which could be useful to guide early triage decisions, including the need for further evaluation or admission, especially in those environments in which resources are limited.
Blood Biomarkers for Traumatic Brain Injury: A Quantitative Assessment of Diagnostic and Prognostic Accuracy
TLDR
The highest-performing biomarkers in each of these categories may provide insight into the pathophysiologies underlying mild and severe TBI, including markers of coagulation and inflammation, structural proteins in the brain, and proteins involved in homeostasis.
Applications of Proteomics in Traumatic Brain Injury: Current Status and Potential Prospects
TLDR
The efforts to lower the risk of secondary injury and improve outcomes for TBI patients can be ascribed to the process of “squeezing oxygenated blood through a swollen brain”.
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