Biomarkers in the Diagnosis of ADHD – Promising Directions

@article{Faraone2014BiomarkersIT,
  title={Biomarkers in the Diagnosis of ADHD – Promising Directions},
  author={Stephen V. Faraone and Cristian Bonvicini and Catia Scassellati},
  journal={Current Psychiatry Reports},
  year={2014},
  volume={16},
  pages={1-20}
}
The etiology and pathogenesis of attention-deficit/hyperactivity disorder (ADHD) are unclear and a more valid diagnosis would certainly be welcomed. Starting from the literature, we built an hypothetical pyramid representing a putative set of biomarkers where, at the top, variants in DAT1 and DRD4 genes are the best candidates for their associations to neuropsychological tasks, activation in specific brain areas, methylphenidate response and gene expression levels. Interesting data come from… Expand
Role of Dopaminergic and Noradrenergic Systems as Potential Biomarkers in ADHD Diagnosis and Treatment
TLDR
Urinary MHPG levels were decreased after stimulants administration only in the responder patients, indicating that MHPG could be a useful predictor of the response to these drugs, and focuses attention on MHPG as a potential mediator of stimulant drug re‐ sponse, in addition to a potential useful biological marker for diagnostic assessment. Expand
Genetics and pharmacogenetics of attention deficit hyperactivity disorder in childhood and adulthood
TLDR
It is speculated that the SLC6A3 gene could be the best potential candidate biomarker for children with ADHD, after evidence of associations between other polymorphisms and ADHD in childhood and not in adulthood. Expand
DRD4 48 bp multiallelic variants as age-population-specific biomarkers in attention-deficit/hyperactivity disorder
TLDR
The results suggest that DRD4 48 bp VNTR variants should be considered as biomarkers to support the diagnosis of ADHD and to predict MPH response, although the accuracy of such a biomarker remains to be further elucidated. Expand
Common and specific genes and peripheral biomarkers in children and adults with attention-deficit/hyperactivity disorder
  • C. Bonvicini, S. Faraone, C. Scassellati
  • Biology, Medicine
  • The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry
  • 2018
TLDR
Through a convergent functional genomics, this review contributes to clarification of which genetic/biological mechanisms differ with age, and some genes/proteins could be potential useful biomarkers to discriminate cADHD from aADHD. Expand
Potential for diagnosis versus therapy monitoring of attention deficit hyperactivity disorder: a new epigenetic biomarker interacting with both genotype and auto-immunity
In view of the need for easily accessible biomarkers, we evaluated in ADHD children the epigenetic status of the 5′-untranslated region (UTR) in the SLC6A3 gene, coding for human dopamine transporterExpand
Imaging genetics in attention-deficit/hyperactivity disorder and related neurodevelopmental domains: state of the art
TLDR
It is found that IG studies on ADHD generally focus on dopaminergic genes and the structure of basal ganglia using structural Magnetic Resonance Imaging (MRI). Expand
A Population-Based Imaging Genetics Study of Inattention/Hyperactivity: Basal Ganglia and Genetic Pathways.
TLDR
ADHD symptoms were marginally related to putamen volume in a population-based sample and there was no evidence for a role of dopamine/norepinephrine, serotonin, or neuritic outgrowth genetic pathways in ADHD symptom severity. Expand
Blood-Bourne MicroRNA Biomarker Evaluation in Attention-Deficit/Hyperactivity Disorder of Han Chinese Individuals: An Exploratory Study
TLDR
As measured in peripheral blood, miRNA-based biomarkers can aid in the differentiation of ADHD in clinical settings and demonstrate good validity in differentiating ADHD patients from control subjects. Expand
From gene to disorder in ADHD: Mapping mechanisms at different levels of complexity
TLDR
Among other findings, it is able to show that ADHD and the intracranial volume are significantly negatively correlated at the global genetic level, resembling earlier phenotypic observations. Expand
SHR/NCrl rats as a model of ADHD can be discriminated from controls based on their brain, blood, or urine metabolomes
TLDR
In the brain, SHR/NCrl rats displayed modifications in metabolic pathways related to energy metabolism and oxidative stress further supporting their importance in the pathophysiology of ADHD bringing news arguments in favor of the Neuroenergetic theory of ADHD. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 106 REFERENCES
Biomarkers for attention-deficit/hyperactivity disorder (ADHD). A consensus report of the WFSBP task force on biological markers and the World Federation of ADHD
  • J. Thome, A. Ehlis, +8 authors M. Gerlach
  • Psychology, Medicine
  • The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry
  • 2012
TLDR
Most likely, no single ADHD biomarker can be identified, however, the use of a combination of markers may help to reduce heterogeneity and to identify homogeneous subtypes of ADHD. Expand
The neurobiology and genetics of Attention-Deficit/Hyperactivity Disorder (ADHD): what every clinician should know.
  • S. Cortese
  • Psychology, Medicine
  • European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society
  • 2012
TLDR
Findings from structural and functional neuroimaging suggest the involvement of developmentally abnormal brain networks related to cognition, attention, emotion and sensorimotor functions in ADHD, which is confirmed by neurophysiological findings. Expand
Progress and Promise of Attention-Deficit Hyperactivity Disorder Pharmacogenetics
One strategy for understanding variability in attention-deficit hyperactivity disorder (ADHD) medication response, and therefore redressing the current trial-and-error approach to ADHD medicationExpand
Neuroimaging in Psychiatric Pharmacogenetics Research: The Promise and Pitfalls
TLDR
Progress in efforts to incorporate neuroimaging into genetics and treatment research on major psychiatric disorders, such as schizophrenia, major depressive disorder, bipolar disorder, attention-deficit/hyperactivity disorder, and addiction is summarized. Expand
Meta-analysis of the association between dopamine transporter genotype and response to methylphenidate treatment in ADHD
TLDR
It is indicated that SLC6A3 VNTR is not a reliable predictor of methylphenidate treatment success in ADHD, and the question of whether other genetic polymorphisms or nongenetic factors may contribute to the observed heterogeneity in treatment response across ADHD subjects is left unanswered. Expand
Familiality and molecular genetics of attention networks in ADHD
  • K. Konrad, A. Dempfle, +11 authors B. Herpertz-Dahlmann
  • Psychology, Medicine
  • American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • 2010
TLDR
The data suggest that the quantitative behavioral ratings of inattentive symptoms might be more useful when searching for new genes associated with ADHD, however, among the ANT measures the executive attention network seems to be best suited for further endophenotype analyses. Expand
Support for association between ADHD and two candidate genes: NET1 and DRD1
  • A. Bobb, A. Addington, +12 authors J. Rapoport
  • Medicine
  • American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • 2005
TLDR
Support is provided for an association between ADHD and polymorphisms in both NET1 and DRD1; polymorphismsIn ten other candidate genes were not associated with ADHD. Expand
The potential of biomarkers in psychiatry: focus on proteomics
TLDR
The potential of proteomic biomarker for better understanding and diagnosis of psychiatric disorders and current putative biomarkers for schizophrenia, depression, autism spectrum disorder and attention deficit/hyperactivity disorder are described. Expand
Brain oscillations as biomarkers in neuropsychiatric disorders: following an interactive panel discussion and synopsis.
  • G. Yener, E. Basar
  • Psychology, Medicine
  • Supplements to Clinical neurophysiology
  • 2013
TLDR
In an extension to conventional anatomical, biochemical and brain imaging biomarkers, the use of neurophysiologic markers may lead to new applications for functional interpretrations and also the possibility to monitor treatments tailored for individuals. Expand
Biomarkers and attention-deficit/hyperactivity disorder: a systematic review and meta-analyses.
TLDR
This study provides evidence for several peripheral biomarkers as being associated with ADHD both in diagnosis and in treatment efficacy, and significant heterogeneity of effect sizes was found for three of the five biomarkers that differentiated ADHD from control subjects. Expand
...
1
2
3
4
5
...