Biomarkers in imaging: realizing radiology's future.

@article{Smith2003BiomarkersII,
  title={Biomarkers in imaging: realizing radiology's future.},
  author={John Joseph Smith and A. G. Sorensen and James Thrall},
  journal={Radiology},
  year={2003},
  volume={227 3},
  pages={633-8}
}
Modern pharmaceuticals and medical devices have provided substantial benefits to patients throughout the world. These benefits come at a high and increasing cost, with development of the typical pharmaceutical requiring 12 years and hundreds of millions of dollars before gaining U.S. Food and Drug Administration marketing approval. Appropriate use of imaging biomarkers--defined as anatomic, physiologic, biochemical, or molecular parameters detectable with imaging methods used to establish the… CONTINUE READING

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