Biomarkers in anal cancer: from biological understanding to stratified treatment

@inproceedings{Jones2017BiomarkersIA,
  title={Biomarkers in anal cancer: from biological understanding to stratified treatment},
  author={Christopher M Jones and Vicky Goh and David J Sebag-Montefiore and Duncan C Gilbert},
  booktitle={British Journal of Cancer},
  year={2017}
}
Squamous cell carcinomas of the anus and anal canal represent a model of a cancer and perhaps the first where level 1 evidence supported primary chemoradiotherapy (CRT) in treating locoregional disease with curative intent. The majority of tumours are associated with infection with oncogenic subtypes of human papilloma virus and this plays a significant role in their sensitivity to treatment. However, not all tumours are cured with CRT and there remain opportunities to improve outcomes in terms… CONTINUE READING
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