Biomarkers in amyotrophic lateral sclerosis: opportunities and limitations

Abstract

Insights into the mechanisms of amyotrophic lateral sclerosis (ALS) have relied predominantly on the study of postmortem tissue. Modern technology has improved the ability of scientists to probe effectively the underlying biology of ALS by examination of genomic, proteomic and physiological changes in patients, as well as to monitor functional and… (More)
DOI: 10.1038/nrneurol.2011.151

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